Consequently both the sire and the dam must possess at least one copy of the mutated gene in order for the offspring to be afflicted. The disorder is recessive, which means that a horse must be homozygous positive or have two copies of the defective gene to suffer from the disease. SCID is therefore a distressing condition for the effected animal and the owners or caregivers, and results in financial loss due to dead foals and veterinary expenses. This happens regardless of the level of veterinary care. Clinical diagnosis of the disease is not straightforward as the symptoms, such as raised temperature, respiratory complications and diarrhoea, are typical of new-born foals with a range of infections.įoals affected by SCID always die from the disorder within the first six months of life. Severe Combined Immunodeficiency Disease (SCID) is an inherited disease seen in pure and part-bred Arab horses.Īnimals with this inherited condition have an enhanced susceptibility to infection and first show signs of disease at between two days and eight weeks of age. The horse is affected with the SCID genetic disorder. SCID SCID – Carrier of two copies of the SCID gene.The horse is a carrier of SCID genetic disorder and there is a 50% chance this horse will pass a SCID allele to its offspring nSCID – Heterozygous horse for SCID gene, both the normal and SCID alleles were detected.nn – Non-carrier of the SCID gene.Tested negative for the SCID mutation.The DNA test verifies the presence recessive SCID mutation and presents results as one of the following: The foals could be tested anytime after birth to determine their SCID genotype and future matings could be rationally planned.The resulting foals would have an equal chance of being a carrier or clear of SCID, but would definitely not be affected. For example, carrier stallions that possess highly desirable traits can now be selectively bred to clear (homozygous normal) mares (and vice versa). Continued breeding of horses that are carriers of the SCID gene is now possible without the worry of producing SCID foals.This information allows breeders to prevent two carriers from breeding, which reduce the chances of producing an SCID foal. The DNA test for SCID helps breeders to identify the animals that are carriers of the SCID mutation.SCID is an inherited disease seen in pure and part-bred Arab horses. DNA test for the Severe Combined Immunodeficiency (SCID).
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